Classic gout marker, but also a sensitive signal of fructose intake, metabolic syndrome, and renal function.
Uric acid is the end product of purine metabolism. Above ~6.8 mg/dL it begins to crystallize in joints (gout) and kidneys (stones). Beyond that, elevated uric acid is increasingly recognized as a contributor to endothelial dysfunction and metabolic syndrome — fructose metabolism specifically raises uric acid, linking sugar intake to CV risk.
Many optimization users find uric acid trends with visceral adiposity and insulin resistance. It drops meaningfully on GLP-1-mediated weight loss.
Uric acid is influenced by: purine-rich foods (organ meats, alcohol — especially beer), fructose intake, renal function (excreted 2/3 renally), thiazide diuretics (raise it), allopurinol (lowers it), dehydration, and insulin resistance. Drops on GLP-1 weight loss and ketogenic diets (with initial transient rise on keto start).
Trend annually in anyone with metabolic goals. Sharp rises with thiazide initiation, fasting, or rapid weight loss are expected. Consistently >7 with symptoms or family history of gout warrants specialist input.
Upload any lab PDF and MyProtocolStack maps your values to Uric Acid and 40+ other biomarkers. StackAI interprets the trend in context of your protocol.
Start tracking →Informational only — not medical advice. Reference ranges vary by lab and individual context. Work with a licensed provider to interpret your specific results.