MacroFactor pioneered adaptive macros and adherence-neutral design. MyProtocolStack adds peptides and labs. Comparing fit for protocol users.
Quick Take MacroFactor is the best-in-class for adaptive macro tracking. Their algorithm learns your metabolism over weeks and adjusts targets dynamically — and their adherence-neutral design (no shame for going over targets) is a UX masterclass. MyProtocolStack covers macros too, but our reason for existing is different: we tie nutrition data to lab biomarkers and peptide protocols in one dashboard. If you only need adaptive macros, MacroFactor is excellent. If you also run peptides or track labs, MacroFactor doesn't reach that far.
MacroFactor was built by Greg Nuckols' team (Stronger by Science) and shipped with a clear thesis: most macro apps make you do the math yourself. You set a target, you log food, you guess whether the target is right. MacroFactor flipped this.
The algorithm uses your weight trend and your food intake to estimate your true metabolic rate, then adjusts your calorie target weekly. If you've been eating 2,400 cal and losing weight faster than expected, MacroFactor raises your target. If you're stalled, it lowers. This handles the "metabolic adaptation" problem most macro apps ignore.
Other strengths:
MacroFactor is exclusively a macro tracker. There's no lab integration, no biomarker tracking, no peptide logging, no cycle planning. The algorithm cares about your weight trend and your food intake. It doesn't know about your tirzepatide titration schedule or your 6-month testosterone trend.
For users running protocols, MacroFactor covers maybe 25% of what they're tracking. The rest — labs, doses, biomarkers, vials — lives in spreadsheets, separate apps, or nowhere.
MyProtocolStack is built for the audience MacroFactor doesn't address: people running peptide, GLP-1, TRT, or hormone optimization protocols who want everything in one dashboard.
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MacroFactor is a paid-only product — no free tier. Monthly is $11.99, annual is $71.88 ($5.99/mo). They offer a 7-day free trial.
MyProtocolStack has a free Explorer plan covering unlimited lab tracking + manual entry + peptide library. Optimizer is $14.99/mo, $90/yr ($7.50/mo annual). The trial is 14 days on paid tiers.
If macros are your only priority, MacroFactor is a few dollars cheaper. If you want labs + peptides + macros bundled, MyProtocolStack costs roughly the same as MacroFactor + a separate lab tracker, with the integration benefit on top.
MyProtocolStack doesn't currently have MacroFactor-style adaptive macros. We use static targets with presets and the user adjusts manually. This is a deliberate trade-off: building an adaptive algorithm well is a hard ML problem (MacroFactor invested years in it), and our priority has been the lab + peptide layer that didn't exist anywhere.
For protocol users, the adaptive macros question is also less critical. When you're running a GLP-1 or a GH peptide, your metabolic rate isn't the dominant variable — the protocol itself is. Tracking the protocol matters more than tracking the perfect calorie target.
MacroFactor is the better adaptive macro tracker. If that's your top priority, use it.
MyProtocolStack covers more ground for protocol users. If you've been running tirzepatide or testosterone or BPC-157 and your tracking lives in three apps and a spreadsheet, MyProtocolStack consolidates it. The macro tracking is good but not adaptive — a tradeoff most protocol users find acceptable.
Some users run both. That works. But the value of one consolidated dashboard is real if you're tracking more than just food.
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*This article is for informational and educational purposes only. MyProtocolStack and MacroFactor are tracking platforms. Neither product diagnoses or treats any condition. Consult a qualified healthcare provider before making changes to any nutrition, peptide, or pharmaceutical protocol.*
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