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Sexual HealthFDA Category 1 - Feb 2026No login required

PT-141 Reconstitution & Dosage Calculator

FDA-approved melanocortin receptor agonist (Vyleesi) for hypoactive sexual desire disorder. Used off-label in both sexes. Onset: 45–90 minutes.

Half-life: 120 minFrequency: As needed (max 1x per 72 hours)Route: Subcutaneous

PT-141 Reconstitution Calculator

Pre-filled with standard PT-141 values. Adjust as needed.

Typical range: 1–2mg per use
RECONSTITUTION PROCESS
BAC H2O10mg1. DRAW 2mL BAC2. INJECT INTO VIAL3. SWIRL TO DISSOLVE4. DRAW 0.20mL DOSE
10mg + 2mL → 5000 mcg/mL
Concentration5000 mcg/mL
Draw volume0.200 mL
Draw to (100-unit syringe)20.0 units
Total doses per vial10 doses
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PT-141 Dosing Guide

Standard: 1–2mg subcutaneously 45–90 min before sexual activity. Maximum once every 72 hours. Duration: up to 12 hours. Start with 1mg to assess tolerance.

Blood markers to track

Blood pressure (PT-141 may temporarily elevate)TestosteroneEstradiol

Note: FDA-approved as Vyleesi. Common effects: flushing, nausea, headache. Monitor BP. Avoid with cardiovascular disease.

Frequently Asked Questions

What is the standard PT-141 dose?

Standard: 1–2mg subcutaneously 45–90 min before sexual activity. Maximum once every 72 hours. Duration: up to 12 hours. Start with 1mg to assess tolerance.

How do I reconstitute PT-141?

Add 2mL of bacteriostatic water to a 10mg vial of PT-141 to get a concentration of 5000 mcg/mL. This gives 1000mcg per 20 units on a 100-unit insulin syringe.

What blood markers should I track while running PT-141?

Common biomarkers tracked alongside PT-141 protocols include Blood pressure (PT-141 may temporarily elevate), Testosterone, Estradiol. Establishing a baseline panel before starting and re-drawing labs at consistent intervals lets you measure changes against your own reference point, generic lab ranges are less informative than your personal trend over time. MyProtocolStack tracks each of these biomarkers in the context of your active PT-141 protocol.

Last reviewed: June 2026. For education and tracking only, not medical advice. Confirm any dose with a licensed healthcare provider.

WHAT TO DO NEXT

You have the dose. Now track whether it’s doing anything.

Log every PT-141 injection alongside your Blood pressure (PT-141 may temporarily elevate)and Testosterone readings. Compare draws over time in your free dashboard, so the next change you make is based on your numbers, not a guess.

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PT-141 protocol guides

PT-141 Protocol: Dosing & Timing

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Testosterone Optimization Guide

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Peptide Injection Guide for Beginners

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NOT MEDICAL ADVICE. FOR INFORMATIONAL USE ONLY. CONSULT A LICENSED HEALTHCARE PROVIDER. · All Calculators · Blog · Home