Sermorelin Reconstitution & Dosage Calculator

Natural GHRH analog (first 29 amino acids) with FDA approval for pediatric GH deficiency. Gentler IGF-1 response, good starting option for GH secretagogue protocols.

Sermorelin Reconstitution Calculator

Pre-filled with standard Sermorelin values. Adjust as needed.

Sermorelin Dosing Guide

Standard: 200–500mcg subcutaneously once daily before bed on empty stomach. Gentler than CJC-1295 or Tesamorelin - good for GH naive users.

Note: FDA-approved for pediatric use. Gentler GH response than CJC-1295. Ideal starting option.

Deep Dive

From vial to syringe: the reconstitution math this calculator runs

Every number this tool returns comes from two inputs you supply: the milligrams of lyophilized sermorelin in the vial and the milliliters of bacteriostatic water you add to dissolve it. Those two figures set the concentration, and concentration is what converts a target dose in micrograms into a mark on the syringe barrel.

Work the default scenario by hand to see the logic. A common sermorelin vial holds 3mg, which is 3,000mcg. Reconstitute it with 3mL of bacteriostatic water and the concentration is 3,000mcg divided by 3mL, or 1,000mcg per mL. On a U-100 insulin syringe, 1mL is marked as 100 units, so each single unit holds 0.01mL, which at this concentration carries 10mcg. A 300mcg dose is therefore 300 divided by 10, or 30 units, drawn to the 30 mark as 0.30mL.

Change one input and the mark moves. Dissolve the same 3mg vial in 1.5mL instead and concentration doubles to 2,000mcg per mL, so each unit now carries 20mcg and the identical 300mcg dose sits at the 15 mark. The dose reaching your body is unchanged. Only the geometry on the barrel changed. That is why the water-volume field is not cosmetic.

Why the unit mark has to be exact

A U-100 unit is a measure of volume, 0.01mL, not a mass. The calculator does the mass-to-volume translation so you read a mark rather than estimate. Precision matters because sermorelin is dosed in the low hundreds of micrograms, where a small barrel error is a large percentage error: at 1,000mcg per mL, a three-unit misread is 30mcg, a full ten percent of a 300mcg dose.

The most common measurement mistakes:

- **Confusing micrograms and milligrams.** 300mcg is 0.3mg. Reading a milligram label figure as the dose is a 1,000-fold error. - **Reusing someone else's unit number.** Their mark only applies if their vial size and water volume match yours exactly. - **Reading units as micrograms.** The 30 mark is 30 units of volume, not 30mcg. - **Ignoring syringe dead space and trapped air bubbles**, which displace volume and shave the delivered dose.

Whenever any input changes, re-run the number rather than reusing an old mark.

What a 10 to 20 minute half-life dictates about timing

Sermorelin is the first 29 amino acids of growth hormone releasing hormone, and it clears the bloodstream in roughly 10 to 20 minutes, degraded rapidly at its N-terminus by the DPP-4 enzyme. That short half-life is the reason the calculator's default schedule is a single subcutaneous dose at bedtime rather than a steady drip.

The pharmacology drives the schedule in three ways. First, a brief pulse mimics the body's own episodic GHRH signaling, and pulsatile exposure is what keeps pituitary somatotroph cells responsive, whereas continuous exposure tends to desensitize them. Second, the largest natural growth hormone pulse occurs during early slow-wave sleep, so a bedtime dose layers the stimulus on top of the endogenous rhythm. Third, growth hormone release is blunted by somatostatin and by elevated glucose and insulin, which is why the fasted, empty-stomach convention exists. None of this is a prescription. It explains why the frequency field defaults the way it does, and why moving or splitting doses changes the expected response.

Titration logic: biomarker-guided, not fixed-step

Dose-escalation strategy is not the same across the compounds in this calculator, and the difference is worth understanding before you change a number. GLP-1 medications use a fixed stepwise schedule for tolerability reasons: tirzepatide, for example, starts at 2.5mg once weekly and increases by 2.5mg roughly every four weeks toward a maintenance dose, the escalation pattern used across the SURPASS and SURMOUNT-1 trials to limit gastrointestinal side effects.

Sermorelin follows a different principle. There is no gastrointestinal escalation ladder to climb. A typical reported approach starts at the lower end of the 200 to 500mcg range and adjusts based on how the IGF-1 lab responds over roughly six weeks, alongside tolerability. The calculator lets you model any dose in that window, but which dose is appropriate, and whether to move within it, is a clinical decision that belongs with a licensed provider reading your labs.

The labs that show whether the dose is landing

Sermorelin works upstream, prompting your own pituitary to release growth hormone, so the readout is indirect. Markers a clinician commonly tracks:

- **IGF-1**: the primary marker. Growth hormone drives hepatic IGF-1 production, and IGF-1 is stable enough across the day to be the practical gauge of whether the axis is being stimulated. A baseline draw and a recheck near six weeks frames the change. - **IGFBP-3**: the main IGF-1 binding protein, which generally moves in parallel and adds context to an IGF-1 reading. - **Fasting glucose**: growth hormone is counter-regulatory to insulin, so a fasting glucose check guards against unwanted metabolic drift.

These are tracking markers to review with a clinician, not targets to chase on your own.

Reconstitution, storage, and handling that affect potency

Sermorelin acetate ships as a fragile lyophilized powder, and how it is handled affects whether the milligrams on the label survive to the syringe. The points below are general stability considerations, not preparation instructions. A licensed provider or compounding pharmacist is the right source for how to handle a specific product.

- **Gentle mixing preserves the peptide.** Guidance for lyophilized peptides generally favors adding the diluent down the inside wall of the vial and swirling rather than shaking, because agitation can shear and denature the molecule. - **Bacteriostatic water differs from plain sterile water.** The benzyl alcohol preservative in bacteriostatic water is what makes a multi-dose vial practical over several days, which is why it is the conventional diluent for repeated draws. - **Cold, dark storage slows degradation.** Reconstituted vials are typically refrigerated at 2 to 8 degrees Celsius and kept out of light. Unreconstituted powder is generally kept refrigerated or frozen. - **The in-use window is short.** Sermorelin is among the less stable peptides once dissolved, so reconstituted potency declines over a few weeks even under correct storage.

Poor storage quietly lowers concentration, which means the mark the calculator produced no longer delivers the dose you entered. When any of these variables is uncertain, re-confirm the plan with your provider rather than trusting an old calculation.

Frequently Asked Questions

Last reviewed: June 2026. For education and tracking only, not medical advice. Confirm any dose with a licensed healthcare provider.

You have the dose. Now track whether it’s doing anything.

Log every Sermorelin injection alongside your IGF-1and IGFBP-3 readings. Compare draws over time in your free dashboard, so the next change you make is based on your numbers, not a guess.

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