Short tetrapeptide studied for telomere and pineal-axis effects in Russian longevity research.
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide developed by Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. The original research identified Epitalon as a bioregulator that stimulates pineal gland activity, including melatonin production, and Russian studies have reported telomere-length effects in cell culture and animal models.
The evidence base is smaller and more Russian-centric than most peptides tracked here. That said, it's widely used in the longevity community as part of "Glow Stack" or cycling protocols. Safety profile appears benign at typical doses.
Typically run as a short cycle (10–20 days at 5–10 mg daily) rather than continuous dosing. Advocates usually cycle 1–2× per year.
Epithalon is proposed to stimulate telomerase activity in certain cell lines, leading to telomere elongation. It also modulates pineal gland function — melatonin production, circadian rhythm — which is why sleep quality is a common self-reported improvement.
5–10 mg SC once daily for 10–20 consecutive days, cycled once or twice per year. Sometimes split AM/PM. Users often pair with GHK-Cu + BPC-157 in a Glow Stack. Evaluating response subjectively (sleep, cognition) is typical; no single reliable biomarker is used.
Education only — not medical advice. Any protocol change should involve your licensed provider.
When running Epithalon, these are the biomarkers most commonly tracked to assess response and safety:
Free calculator for Epithalon reconstitution math — vial size, BAC water volume, and exact syringe units.
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