CJC-1295
Synthetic GHRH analog that pairs with Ipamorelin for synergistic GH-pulse amplification.
30 residues· First described 2005
Sermorelin analog with Drug Affinity Complex (DAC) or no-DAC (Mod GRF 1-29) variants
Overview
CJC-1295 is a synthetic analog of the first 29 amino acids of growth hormone releasing hormone (GHRH), engineered for resistance to degradation. Two versions exist: "no DAC" (short half-life, ~30 min, pairs with ipamorelin for natural pulsatile release) and "with DAC" (drug affinity complex, 7-day half-life, tonic elevation). Community consensus strongly prefers no-DAC for most optimization protocols - pulsatile release is more physiologic.
The classic stack is CJC-1295 no-DAC 100–200 mcg + Ipamorelin 200–300 mcg injected together 1–3× daily. GHRH and GHRP act on different receptors (GHRH-R and GHSR) so combining them amplifies GH release beyond what either produces alone.
Response is similar to ipamorelin alone for IGF-1 elevation; the combination adds magnitude and improves consistency. Good for GH secretagogue newcomers who want a cleaner alternative to tesamorelin.
Mechanism of Action
CJC-1295 activates the GHRH receptor on the anterior pituitary, stimulating endogenous GH release. The "no DAC" version has a short half-life (~30 min), which preserves natural pulsatile GH rhythm. The "with DAC" version binds to albumin via its DAC moiety for extended half-life, producing tonic rather than pulsatile release.
Community Usage Patterns
No-DAC: 100–200 mcg SC, 1–3× per day, typically stacked with ipamorelin at same time points. Best on empty stomach. With DAC: 1–2 mg weekly or every 10 days. Most optimization protocols use no-DAC. 12-week cycles with IGF-1 check at 6–8 weeks.
Education only - not medical advice. Any protocol change should involve your licensed provider.
Biomarkers to Track
When running CJC-1295, these are the biomarkers most commonly tracked to assess response and safety:
Reconstitution Calculator
Free calculator for CJC-1295 reconstitution math - vial size, BAC water volume, and exact syringe units.
Open CJC-1295 calculator →Side Effects & Monitoring
What CJC-1295 side effects are commonly reported, when they appear, the red flags worth a provider call, and the biomarkers that catch issues early.
CJC-1295 side effects & what to track →Results & What to Track
What CJC-1295 results actually look like in the data - the markers to measure, when they tend to move, and how to tell a real result from placebo.
CJC-1295 results & how to measure them →Related Reading
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Conditions CJC-1295 is Commonly Researched For
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Start tracking →This page is informational and does not constitute medical advice. MyProtocolStack is a tracking and education platform. Work with a licensed provider before starting, changing, or stopping any protocol.