Synthetic GHRH analog that pairs with Ipamorelin for synergistic GH-pulse amplification.
CJC-1295 is a synthetic analog of the first 29 amino acids of growth hormone releasing hormone (GHRH), engineered for resistance to degradation. Two versions exist: "no DAC" (short half-life, ~30 min, pairs with ipamorelin for natural pulsatile release) and "with DAC" (drug affinity complex, 7-day half-life, tonic elevation). Community consensus strongly prefers no-DAC for most optimization protocols — pulsatile release is more physiologic.
The classic stack is CJC-1295 no-DAC 100–200 mcg + Ipamorelin 200–300 mcg injected together 1–3× daily. GHRH and GHRP act on different receptors (GHRH-R and GHSR) so combining them amplifies GH release beyond what either produces alone.
Response is similar to ipamorelin alone for IGF-1 elevation; the combination adds magnitude and improves consistency. Good for GH secretagogue newcomers who want a cleaner alternative to tesamorelin.
CJC-1295 activates the GHRH receptor on the anterior pituitary, stimulating endogenous GH release. The "no DAC" version has a short half-life (~30 min), which preserves natural pulsatile GH rhythm. The "with DAC" version binds to albumin via its DAC moiety for extended half-life, producing tonic rather than pulsatile release.
No-DAC: 100–200 mcg SC, 1–3× per day, typically stacked with ipamorelin at same time points. Best on empty stomach. With DAC: 1–2 mg weekly or every 10 days. Most optimization protocols use no-DAC. 12-week cycles with IGF-1 check at 6–8 weeks.
Education only — not medical advice. Any protocol change should involve your licensed provider.
When running CJC-1295, these are the biomarkers most commonly tracked to assess response and safety:
Free calculator for CJC-1295 reconstitution math — vial size, BAC water volume, and exact syringe units.
Open CJC-1295 calculator →Log doses, upload your lab PDFs, and let StackAI read your panel in context of what you're actually running. Free to start.
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