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Educational comparison - not medical advice. This page compares two compounds for informational purposes. Neither is recommended as treatment. Any protocol decision is a conversation with your licensed healthcare provider.
Home/Peptides/Tesamorelin vs CJC-1295
HEAD-TO-HEAD COMPARISON

Tesamorelin vs CJC-1295

Users choosing between GHRH-class peptides for GH-axis support.

OPTION A
Tesamorelin
Tesamorelin (Egrifta)
FDA-approved GHRH analog with the strongest IGF-1 response of any peptide in its class.
Full profile →
OPTION B
CJC-1295
CJC-1295 (no DAC)
Synthetic GHRH analog that pairs with Ipamorelin for synergistic GH-pulse amplification.
Full profile →
THE CORE DIFFERENCE

Tesamorelin is a stabilized GHRH analog with ~26 min half-life - strong pulsatile GH release, daily dosing, FDA-approved. CJC-1295 is also GHRH-based but modified with a DAC (drug affinity complex) extending half-life to ~7 days - provides tonic GH elevation rather than pulses. Community preference tends toward tesamorelin for the more physiologic pulse profile; CJC-1295 users often choose the "no DAC" version for the same reason.

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FEATURE COMPARISON
Tesamorelin
CJC-1295
Full name
Tesamorelin (Egrifta)
CJC-1295 (no DAC)
Category
Growth
Growth
FDA status
FDA-approved as Egrifta for HIV-associated lipodystrophy. Widely used off-label.
Not FDA-approved. Category 1 under the 2026 reclassification.
Half-life
~26 minutes
~30 minutes (no DAC); several days (with DAC)
Typical dosing
1–2 mg nightly, subcutaneous, on an empty stomach
100–200 mcg SC, 1–3× per day (typically no-DAC version)
Route
Subcutaneous (abdominal)
Subcutaneous
Classification
Synthetic GHRH (growth hormone releasing hormone) analog
Synthetic GHRH (1-29) analog
BIOMARKERS COMMONLY TRACKED
On Tesamorelin
  • • IGF-1 (primary)
  • • IGFBP-3
  • • Fasting glucose
  • • HbA1c
  • • Fasting insulin
On CJC-1295
  • • IGF-1
  • • IGFBP-3
  • • Fasting glucose
  • • Fasting insulin
  • • Hematocrit
CALCULATOR
Tesamorelin reconstitution →
CALCULATOR
CJC-1295 reconstitution →
CONDITIONS USERS RESEARCH THESE FOR
Informational only - neither compound is presented as a treatment for any condition. These are contexts in which users research these compounds and discuss them with their licensed provider.
RECOVERY
Poor Sleep Quality
Chronic insufficient or fragmented sleep - upstream of most metabolic, hormonal, and cognitive markers.
METABOLIC
Elevated Visceral Fat
The metabolically-active abdominal fat linked to cardiovascular + insulin-resistance risk. Hard to see; visible in labs.
RELATED COMPARISONS
Tesamorelin vs Ipamorelin
Ipamorelin vs CJC-1295
Sermorelin vs Tesamorelin
MK-677 vs Tesamorelin
HGH vs Tesamorelin
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Informational comparison only - not medical advice. Research-stage compounds discussed are not FDA-approved unless specifically noted. Any protocol decision should be made with a licensed healthcare provider.