Educational comparison - not medical advice. This page compares two compounds for informational purposes. Neither is recommended as treatment. Any protocol decision is a conversation with your licensed healthcare provider.
HEAD-TO-HEAD COMPARISON
Sermorelin vs Tesamorelin
Users new to GH-axis peptides choosing a starting compound.
OPTION A
Sermorelin
Sermorelin (GHRH 1-29)
Original GHRH analog - gentlest response in the GH secretagogue family, good entry point for beginners.
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OPTION B
Tesamorelin
Tesamorelin (Egrifta)
FDA-approved GHRH analog with the strongest IGF-1 response of any peptide in its class.
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THE CORE DIFFERENCE
Sermorelin is the original GHRH (1-29) - very short half-life (~10-20 min), gentler GH response. Tesamorelin is the stabilized, longer-acting GHRH analog - ~26 min half-life, stronger IGF-1 elevation. Sermorelin is often a starting point for GH-axis work due to its gentleness; users seeking larger response typically graduate to tesamorelin or stack approaches.
BEST FOR
Each protocol guide pairs the relevant compounds with the supplement stack that supports them and the biomarkers that show whether it’s working.
BIOMARKERS COMMONLY TRACKED
On Sermorelin
- • IGF-1
- • IGFBP-3
- • Fasting glucose
On Tesamorelin
- • IGF-1 (primary)
- • IGFBP-3
- • Fasting glucose
- • HbA1c
- • Fasting insulin
CONDITIONS USERS RESEARCH THESE FOR
Informational only - neither compound is presented as a treatment for any condition. These are contexts in which users research these compounds and discuss them with their licensed provider.
RELATED COMPARISONS
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Start tracking free →Informational comparison only - not medical advice. Research-stage compounds discussed are not FDA-approved unless specifically noted. Any protocol decision should be made with a licensed healthcare provider.