Sermorelin vs Tesamorelin
Users new to GH-axis peptides choosing a starting compound.
Sermorelin is the original GHRH (1-29) - very short half-life (~10-20 min), gentler GH response. Tesamorelin is the stabilized, longer-acting GHRH analog - ~26 min half-life, stronger IGF-1 elevation. Key specs: Sermorelin (Growth, ~10–20 minutes, Subcutaneous) vs Tesamorelin (Growth, ~26 minutes, Subcutaneous (abdominal)).
Sermorelin is the original GHRH (1-29) - very short half-life (~10-20 min), gentler GH response. Tesamorelin is the stabilized, longer-acting GHRH analog - ~26 min half-life, stronger IGF-1 elevation. Sermorelin is often a starting point for GH-axis work due to its gentleness; users seeking larger response typically graduate to tesamorelin or stack approaches.
- • IGF-1
- • IGFBP-3
- • Fasting glucose
- • IGF-1 (primary)
- • IGFBP-3
- • Fasting glucose
- • HbA1c
- • Fasting insulin
What is the difference between Sermorelin and Tesamorelin?
Sermorelin is the original GHRH (1-29) - very short half-life (~10-20 min), gentler GH response. Tesamorelin is the stabilized, longer-acting GHRH analog - ~26 min half-life, stronger IGF-1 elevation. Sermorelin is often a starting point for GH-axis work due to its gentleness; users seeking larger response typically graduate to tesamorelin or stack approaches.
Who typically researches Sermorelin vs Tesamorelin?
Users new to GH-axis peptides choosing a starting compound. Sermorelin (Growth, ~10–20 minutes, Subcutaneous) and Tesamorelin (Growth, ~26 minutes, Subcutaneous (abdominal)) differ in mechanism and dosing cadence - the right choice depends on protocol goals, biomarker baseline, and provider guidance. MyProtocolStack lets you log doses and lab values for both side-by-side if you're cycling between them.
What blood markers do users track on Sermorelin or Tesamorelin?
Biomarkers commonly tracked across Sermorelin and Tesamorelin protocols include IGF-1, IGFBP-3, Fasting glucose, IGF-1 (primary), HbA1c, Fasting insulin. Establishing a baseline before starting and re-drawing at consistent intervals lets you measure each compound's effect against your own reference point - generic lab ranges are less informative than your personal trend over time. MyProtocolStack tracks these biomarkers in the context of whichever compound you're currently running.
Log doses, upload labs, watch the biomarkers trend. StackAI reads your panel in context of what you're actually running.
Start tracking free →Informational comparison only - not medical advice. Research-stage compounds discussed are not FDA-approved unless specifically noted. Any protocol decision should be made with a licensed healthcare provider.