Educational comparison — not medical advice. This page compares two compounds for informational purposes. Neither is recommended as treatment. Any protocol decision is a conversation with your licensed healthcare provider.
Home/Peptides/Sermorelin vs Tesamorelin
HEAD-TO-HEAD COMPARISON

Sermorelin vs Tesamorelin

Users new to GH-axis peptides choosing a starting compound.

OPTION A
Sermorelin
Sermorelin (GHRH 1-29)
Original GHRH analog — gentlest response in the GH secretagogue family, good entry point for beginners.
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OPTION B
Tesamorelin
Tesamorelin (Egrifta)
FDA-approved GHRH analog with the strongest IGF-1 response of any peptide in its class.
Full profile →
THE CORE DIFFERENCE

Sermorelin is the original GHRH (1-29) — very short half-life (~10-20 min), gentler GH response. Tesamorelin is the stabilized, longer-acting GHRH analog — ~26 min half-life, stronger IGF-1 elevation. Sermorelin is often a starting point for GH-axis work due to its gentleness; users seeking larger response typically graduate to tesamorelin or stack approaches.

FEATURE COMPARISON
Sermorelin
Tesamorelin
Full name
Sermorelin (GHRH 1-29)
Tesamorelin (Egrifta)
Category
Growth
Growth
FDA status
Historically FDA-approved (Geref) before discontinuation. Currently only via compounding.
FDA-approved as Egrifta for HIV-associated lipodystrophy. Widely used off-label.
Half-life
~10–20 minutes
~26 minutes
Typical dosing
200–500 mcg SC before bed
1–2 mg nightly, subcutaneous, on an empty stomach
Route
Subcutaneous
Subcutaneous (abdominal)
Classification
GHRH 1-29 analog
Synthetic GHRH (growth hormone releasing hormone) analog
BIOMARKERS COMMONLY TRACKED
On Sermorelin
  • • IGF-1
  • • IGFBP-3
  • • Fasting glucose
On Tesamorelin
  • • IGF-1 (primary)
  • • IGFBP-3
  • • Fasting glucose
  • • HbA1c
  • • Fasting insulin
CALCULATOR
Sermorelin reconstitution →
CALCULATOR
Tesamorelin reconstitution →
CONDITIONS USERS RESEARCH THESE FOR
Informational only — neither compound is presented as a treatment for any condition. These are contexts in which users research these compounds and discuss them with their licensed provider.
RECOVERY
Poor Sleep Quality
Chronic insufficient or fragmented sleep — upstream of most metabolic, hormonal, and cognitive markers.
METABOLIC
Elevated Visceral Fat
The metabolically-active abdominal fat linked to cardiovascular + insulin-resistance risk. Hard to see; visible in labs.
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Informational comparison only — not medical advice. Research-stage compounds discussed are not FDA-approved unless specifically noted. Any protocol decision should be made with a licensed healthcare provider.