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Educational comparison - not medical advice. This page compares two compounds for informational purposes. Neither is recommended as treatment. Any protocol decision is a conversation with your licensed healthcare provider.
Home/Peptides/Tesamorelin vs Ipamorelin
HEAD-TO-HEAD COMPARISON

Tesamorelin vs Ipamorelin

Users discussing GH-axis peptide options with their clinician for body composition or recovery.

QUICK ANSWER

Tesamorelin is a GHRH analog - FDA-approved (Egrifta) for HIV-lipodystrophy, strong IGF-1 elevation (40-80%) at 1-2mg nightly. Ipamorelin is a GHRP (ghrelin receptor agonist) - milder IGF-1 response alone, but synergistic when stacked with CJC-1295 no-DAC. Key specs: Tesamorelin (Growth, ~26 minutes, Subcutaneous (abdominal)) vs Ipamorelin (Growth, ~2 hours, Subcutaneous).

OPTION A
Tesamorelin
Tesamorelin (Egrifta)
FDA-approved GHRH analog with the strongest IGF-1 response of any peptide in its class.
Full profile →
OPTION B
Ipamorelin
Ipamorelin
Selective GH secretagogue that pairs with CJC-1295 as the gold-standard gentle GH-pulse stack.
Full profile →
THE CORE DIFFERENCE

Tesamorelin is a GHRH analog - FDA-approved (Egrifta) for HIV-lipodystrophy, strong IGF-1 elevation (40-80%) at 1-2mg nightly. Ipamorelin is a GHRP (ghrelin receptor agonist) - milder IGF-1 response alone, but synergistic when stacked with CJC-1295 no-DAC. Tesamorelin preferred when max IGF-1 response desired; ipamorelin + CJC-1295 preferred for cleaner pulsatile profile and lower cost.

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FEATURE COMPARISON
Tesamorelin
Ipamorelin
Full name
Tesamorelin (Egrifta)
Ipamorelin
Category
Growth
Growth
FDA status
FDA-approved as Egrifta for HIV-associated lipodystrophy. Widely used off-label.
Not FDA-approved. Category 1 under the 2026 reclassification.
Half-life
~26 minutes
~2 hours
Typical dosing
1–2 mg nightly, subcutaneous, on an empty stomach
200–300 mcg SC, 1–3× per day
Route
Subcutaneous (abdominal)
Subcutaneous
Classification
Synthetic GHRH (growth hormone releasing hormone) analog
Synthetic pentapeptide GHRP
BIOMARKERS COMMONLY TRACKED
On Tesamorelin
  • • IGF-1 (primary)
  • • IGFBP-3
  • • Fasting glucose
  • • HbA1c
  • • Fasting insulin
On Ipamorelin
  • • IGF-1
  • • IGFBP-3
  • • Fasting glucose
  • • Fasting insulin
CALCULATOR
Tesamorelin reconstitution →
CALCULATOR
Ipamorelin reconstitution →
CONDITIONS USERS RESEARCH THESE FOR
Informational only - neither compound is presented as a treatment for any condition. These are contexts in which users research these compounds and discuss them with their licensed provider.
RECOVERY
Poor Sleep Quality
Chronic insufficient or fragmented sleep - upstream of most metabolic, hormonal, and cognitive markers.
METABOLIC
Elevated Visceral Fat
The metabolically-active abdominal fat linked to cardiovascular + insulin-resistance risk. Hard to see; visible in labs.
RELATED COMPARISONS
Tesamorelin vs CJC-1295
Ipamorelin vs CJC-1295
Sermorelin vs Tesamorelin
MK-677 vs Tesamorelin
HGH vs Tesamorelin
FREQUENTLY ASKED QUESTIONS

What is the difference between Tesamorelin and Ipamorelin?

Tesamorelin is a GHRH analog - FDA-approved (Egrifta) for HIV-lipodystrophy, strong IGF-1 elevation (40-80%) at 1-2mg nightly. Ipamorelin is a GHRP (ghrelin receptor agonist) - milder IGF-1 response alone, but synergistic when stacked with CJC-1295 no-DAC. Tesamorelin preferred when max IGF-1 response desired; ipamorelin + CJC-1295 preferred for cleaner pulsatile profile and lower cost.

Who typically researches Tesamorelin vs Ipamorelin?

Users discussing GH-axis peptide options with their clinician for body composition or recovery. Tesamorelin (Growth, ~26 minutes, Subcutaneous (abdominal)) and Ipamorelin (Growth, ~2 hours, Subcutaneous) differ in mechanism and dosing cadence - the right choice depends on protocol goals, biomarker baseline, and provider guidance. MyProtocolStack lets you log doses and lab values for both side-by-side if you're cycling between them.

What blood markers do users track on Tesamorelin or Ipamorelin?

Biomarkers commonly tracked across Tesamorelin and Ipamorelin protocols include IGF-1 (primary), IGFBP-3, Fasting glucose, HbA1c, Fasting insulin, IGF-1. Establishing a baseline before starting and re-drawing at consistent intervals lets you measure each compound's effect against your own reference point - generic lab ranges are less informative than your personal trend over time. MyProtocolStack tracks these biomarkers in the context of whichever compound you're currently running.

Whichever you're tracking, we built the dashboard for it.

Log doses, upload labs, watch the biomarkers trend. StackAI reads your panel in context of what you're actually running.

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Informational comparison only - not medical advice. Research-stage compounds discussed are not FDA-approved unless specifically noted. Any protocol decision should be made with a licensed healthcare provider.