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Educational comparison - not medical advice. This page compares two compounds for informational purposes. Neither is recommended as treatment. Any protocol decision is a conversation with your licensed healthcare provider.
Home/Peptides/Tesamorelin vs Ipamorelin
HEAD-TO-HEAD COMPARISON

Tesamorelin vs Ipamorelin

Users discussing GH-axis peptide options with their clinician for body composition or recovery.

OPTION A
Tesamorelin
Tesamorelin (Egrifta)
FDA-approved GHRH analog with the strongest IGF-1 response of any peptide in its class.
Full profile →
OPTION B
Ipamorelin
Ipamorelin
Selective GH secretagogue that pairs with CJC-1295 as the gold-standard gentle GH-pulse stack.
Full profile →
THE CORE DIFFERENCE

Tesamorelin is a GHRH analog - FDA-approved (Egrifta) for HIV-lipodystrophy, strong IGF-1 elevation (40-80%) at 1-2mg nightly. Ipamorelin is a GHRP (ghrelin receptor agonist) - milder IGF-1 response alone, but synergistic when stacked with CJC-1295 no-DAC. Tesamorelin preferred when max IGF-1 response desired; ipamorelin + CJC-1295 preferred for cleaner pulsatile profile and lower cost.

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Each protocol guide pairs the relevant compounds with the supplement stack that supports them and the biomarkers that show whether it’s working.
FEATURE COMPARISON
Tesamorelin
Ipamorelin
Full name
Tesamorelin (Egrifta)
Ipamorelin
Category
Growth
Growth
FDA status
FDA-approved as Egrifta for HIV-associated lipodystrophy. Widely used off-label.
Not FDA-approved. Category 1 under the 2026 reclassification.
Half-life
~26 minutes
~2 hours
Typical dosing
1–2 mg nightly, subcutaneous, on an empty stomach
200–300 mcg SC, 1–3× per day
Route
Subcutaneous (abdominal)
Subcutaneous
Classification
Synthetic GHRH (growth hormone releasing hormone) analog
Synthetic pentapeptide GHRP
BIOMARKERS COMMONLY TRACKED
On Tesamorelin
  • • IGF-1 (primary)
  • • IGFBP-3
  • • Fasting glucose
  • • HbA1c
  • • Fasting insulin
On Ipamorelin
  • • IGF-1
  • • IGFBP-3
  • • Fasting glucose
  • • Fasting insulin
CALCULATOR
Tesamorelin reconstitution →
CALCULATOR
Ipamorelin reconstitution →
CONDITIONS USERS RESEARCH THESE FOR
Informational only - neither compound is presented as a treatment for any condition. These are contexts in which users research these compounds and discuss them with their licensed provider.
RECOVERY
Poor Sleep Quality
Chronic insufficient or fragmented sleep - upstream of most metabolic, hormonal, and cognitive markers.
METABOLIC
Elevated Visceral Fat
The metabolically-active abdominal fat linked to cardiovascular + insulin-resistance risk. Hard to see; visible in labs.
RELATED COMPARISONS
Tesamorelin vs CJC-1295
Ipamorelin vs CJC-1295
Sermorelin vs Tesamorelin
MK-677 vs Tesamorelin
HGH vs Tesamorelin
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Informational comparison only - not medical advice. Research-stage compounds discussed are not FDA-approved unless specifically noted. Any protocol decision should be made with a licensed healthcare provider.