Educational comparison — not medical advice. This page compares two compounds for informational purposes. Neither is recommended as treatment. Any protocol decision is a conversation with your licensed healthcare provider.
Home/Peptides/Tesamorelin vs Ipamorelin
HEAD-TO-HEAD COMPARISON

Tesamorelin vs Ipamorelin

Users discussing GH-axis peptide options with their clinician for body composition or recovery.

OPTION A
Tesamorelin
Tesamorelin (Egrifta)
FDA-approved GHRH analog with the strongest IGF-1 response of any peptide in its class.
Full profile →
OPTION B
Ipamorelin
Ipamorelin
Selective GH secretagogue that pairs with CJC-1295 as the gold-standard gentle GH-pulse stack.
Full profile →
THE CORE DIFFERENCE

Tesamorelin is a GHRH analog — FDA-approved (Egrifta) for HIV-lipodystrophy, strong IGF-1 elevation (40-80%) at 1-2mg nightly. Ipamorelin is a GHRP (ghrelin receptor agonist) — milder IGF-1 response alone, but synergistic when stacked with CJC-1295 no-DAC. Tesamorelin preferred when max IGF-1 response desired; ipamorelin + CJC-1295 preferred for cleaner pulsatile profile and lower cost.

FEATURE COMPARISON
Tesamorelin
Ipamorelin
Full name
Tesamorelin (Egrifta)
Ipamorelin
Category
Growth
Growth
FDA status
FDA-approved as Egrifta for HIV-associated lipodystrophy. Widely used off-label.
Not FDA-approved. Category 1 under the 2026 reclassification.
Half-life
~26 minutes
~2 hours
Typical dosing
1–2 mg nightly, subcutaneous, on an empty stomach
200–300 mcg SC, 1–3× per day
Route
Subcutaneous (abdominal)
Subcutaneous
Classification
Synthetic GHRH (growth hormone releasing hormone) analog
Synthetic pentapeptide GHRP
BIOMARKERS COMMONLY TRACKED
On Tesamorelin
  • • IGF-1 (primary)
  • • IGFBP-3
  • • Fasting glucose
  • • HbA1c
  • • Fasting insulin
On Ipamorelin
  • • IGF-1
  • • IGFBP-3
  • • Fasting glucose
  • • Fasting insulin
CALCULATOR
Tesamorelin reconstitution →
CALCULATOR
Ipamorelin reconstitution →
CONDITIONS USERS RESEARCH THESE FOR
Informational only — neither compound is presented as a treatment for any condition. These are contexts in which users research these compounds and discuss them with their licensed provider.
RECOVERY
Poor Sleep Quality
Chronic insufficient or fragmented sleep — upstream of most metabolic, hormonal, and cognitive markers.
METABOLIC
Elevated Visceral Fat
The metabolically-active abdominal fat linked to cardiovascular + insulin-resistance risk. Hard to see; visible in labs.
RELATED COMPARISONS
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Sermorelin vs Tesamorelin
MK-677 vs Tesamorelin
HGH vs Tesamorelin
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Informational comparison only — not medical advice. Research-stage compounds discussed are not FDA-approved unless specifically noted. Any protocol decision should be made with a licensed healthcare provider.