Selective GH secretagogue that pairs with CJC-1295 as the gold-standard gentle GH-pulse stack.
Ipamorelin is a selective growth hormone releasing peptide (GHRP) that stimulates pituitary GH release without the cortisol and prolactin side effects that complicate older GHRPs like GHRP-2 and GHRP-6. This clean profile is why it's paired with CJC-1295 (no DAC) as the most widely recommended GH secretagogue stack in the optimization community.
Used alone, ipamorelin produces modest IGF-1 elevation. Paired with CJC-1295 no-DAC, the combination synergistically amplifies natural GH pulses — a more physiologic approach than exogenous HGH.
Response is typically milder than tesamorelin but side-effect profile is cleaner. Good starting point for GH secretagogue protocols, especially for users who reacted poorly to more aggressive compounds.
Ipamorelin binds the GHSR (growth hormone secretagogue receptor / ghrelin receptor) with high selectivity, triggering GH release from the pituitary. Unlike GHRP-2 and GHRP-6, it does not meaningfully activate ACTH, cortisol, or prolactin pathways — making it a cleaner tool for isolating the GH-axis effect.
200–300 mcg SC, 1–3× daily on an empty stomach. Most common pattern: AM fasted + before bed. Typically stacked with CJC-1295 (no DAC) 100–200 mcg at same time points. 12–16 week cycles with IGF-1 assessed at 6–8 weeks.
Education only — not medical advice. Any protocol change should involve your licensed provider.
When running Ipamorelin, these are the biomarkers most commonly tracked to assess response and safety:
Free calculator for Ipamorelin reconstitution math — vial size, BAC water volume, and exact syringe units.
Open Ipamorelin calculator →Log doses, upload your lab PDFs, and let StackAI read your panel in context of what you're actually running. Free to start.
Start tracking →This page is informational and does not constitute medical advice. MyProtocolStack is a tracking and education platform. Work with a licensed provider before starting, changing, or stopping any protocol.